Oxidative Stress And Inflammatory Mechanisms in Obesity, Diabetes And the Metabolic Syndrome

Characterized by obesity, insulin resistance, dyslipidemia, and hypertension, metabolic syndrome is associated with the risks of type 2 diabetes mellitus and cardiovascular disease. Obesity, which increases the incidence of atherosclerotic cardiovascular disease and subsequently leads to increased oxidative stress and inflammation, appears to play a central role in the progression of the syndrome. Evidence of inflammatory processes in accumulated fat appears to be an early initiator of metabolic syndrome. Likewise, the more active angiotensin system in obesity may contribute to even greater oxidative stress that serves as a key signaling event in vascular remodeling. These factors strengthen obesity's association with oxidative stress. Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome is designed to encourage the exploration and development of evidence-based nutritional and pharmacological therapies. It is hoped that these therapies will attenuate the impact of obesity-induced insulin resistance and ensuing metabolic syndrome. The book offers readers a greater understanding of the molecular mechanisms that underlie inflammation and oxidative stress. Edited by two of the world's leading authorities on oxidative stress, the book's chapters report on cutting-edge research that explores the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes in obesity and type 2 diabetes. It also brings together research on the molecular mechanisms inherent in the progression of metabolic stress, and includes phenotypic perspectives, while also discussing the role of dietary factors, including the importance of micronutrients. The chapter authors, each one a leading expert in his or her field, provide perspectives on the different components of metabolic stress and obesity and their associations with oxidative stress and inflammation. The book fills a unique role as a base of knowledge for those researchers seeking to develop nutritional and or pharmacological therapies, as well as those clinicians seeking to grasp a better understanding of this increasingly common disease process.Packer Lester Staff is the author of 'Oxidative Stress And Inflammatory Mechanisms in Obesity, Diabetes And the Metabolic Syndrome ', published 2007 under ISBN 9781420043785 and ISBN 1420043781.