Molecular Approaches to Controlling Cancer

Symposium ParticipantsDedicationForeword Cancer Genetics and GenomesOncogenes Come of Age H. Varmus, W. Pao, K. Politi, K. Podsypanina, and Y.–C.N. DuCommon and Contrasting Genomic Profiles among the Major Human Lung Cancer Subtypes G. Tonon, C. Brennan, A. Protopopov, G. Maulik, B. Feng, Y. Zhang, D.B. Khatry, M.J. You, A.J. Aguirre, E.S. Martin, Z. Yang, H. Ji, L. Chin, K.–K. Wong, and R.A. DePinho“Lineage Addiction” in Human Cancer: Lessons from Integrated Genomics L.A. Garraway, B.A. Weir, X. Zhao, H. Widlund, R. Beroukhim, A. Berger, D. Rimm, M.A. Rubin, D.E. Fisher, M.L. Meyerson, and W.R. SellersPolygenic Inherited Predisposition to Breast Cancer B.A.J. Ponder, A. Antoniou, A. Dunning, D.F. Easton, and P.D.P. PharoahSomatic Mutations in Human Cancer: Insights from Resequencing the Protein Kinase Gene Family P.A. Futreal, R. Wooster, and M.R. StrattonHigh–Resolution ROMA CGH and FISH Analysis of Aneuploid and Diploid Breast Tumors J. Hicks, L. Muthuswamy, A. Krasnitz, N. Navin, M. Riggs, V. Grubor, D. Esposito, J. Alexander, J. Troge, M. Wigler, S. Maner, P. Lundin, and A. ZetterbergDuctal Pancreatic Cancer in Humans and Mice D.A. Tuveson and S.R. HingoraniDetection of Oncogenic Mutations in the EGFR Gene in Lung Adenocarcinoma with Differential Sensitivity to EGFR Tyrosine Kinase Inhibitors R.K. Thomas, H. Greulich, Y. Yuza, J.C. Lee, T. Tengs, W. Feng, T.–H. Chen, E. Nickerson, J. Simons, M. Egholm, J.M. Rothberg, W.R. Sellers, and M.L. MeyersonTwo Decades of Cancer Genetics: From Specificity to Pleiotropic Networks S. Grisendi and P.P. Pandolfi DNA Damage ResponseAbnormalities of the Inactive X Chromosome Are a Common Feature of BRCA1 Mutant and Sporadic Basal–like Breast Cancer S. Ganesan, A.L. Richardson, Z.C. Wang, J.D. Iglehart, A. Miron, J. Feunteun, D. Silver, and D.M. LivingstonThe ATM–dependent DNA Damage Signaling Pathway R. Kitagawa and M.B. KastanSingle–Nucleotide Polymorphisms in the p53 Pathway S.L. Harris, G. Gil, W. Hu, H. Robins, E. Bond, K. Hirshfield, Z. Feng, X. Yu, A.K. Teresky, G. Bond, and A.J. LevineTranscriptional Regulation by p53 and p73 M. Lokshin, T. Tanaka, and C. Privesp53–Dependent and –Independent Functions of the Arf Tumor Suppressor C.J. Sherr, D. Bertwistle, W. den Besten, M.–L. Kuo, M. Sugimoto, K. Tago, R.T. Williams, F. Zindy, and M.F. RousselExploiting the DNA Repair Defect in BRCA Mutant Cells in the Design of New Therapeutic Strategies for Cancer A.N.J. Tutt, C.J. Lord, N. McCabe, H. Farmer, N. Turner, N.M. Martin, S.P. Jackson, G.C.M. Smith, and A. Ashworth Cancer Biology and Stem CellsIdentifying Site–specific Metastasis Genes and Functions G.P. Gupta, A.J. Minn, Y. Kang, P.M. Siegel, I. Serganova, C. Cordon–Cardo, A.B. Olshen, W.L. Gerald, and J. MassagueThe von Hippel–Lindau Tumor Suppressor Protein: Roles in Cancer and Oxygen Sensing W.G. Kaelin, Jr.The Src Substrate Tks5, Podosomes (Invadopodia), and Cancer Cell Invasion S.A. Courtneidge, E.F. Azucena, Jr., I. Pass, D.F. Seals, and L. TesfayModeling Neurofibromatosis Type 1 Tumors in the Mouse for Therapeutic Intervention L.F. Parada, C.–H. Kwon, and Y. ZhuStem Cell Self–Renewal and Cancer Cell Proliferation Are Regulated by Common Networks That Balance the Activation of Proto–oncogenes and Tumor Suppressors R. Pardal, A.V. Molofsky, S. He, and S.J. MorrisonProstate Stem Cells and Prostate Cancer D.A. Lawson, L. Xin, R. Lukacs, Q. Xu, D. Cheng, and O.N. Witte Telomeres, Senescence, and AgingTelomere–related Genome Instability in Cancer T. de LangeTelomerase and Cancer Stem Cells M. Armanios and C.W. GreiderRegulation of Telomerase by Human Papillomaviruses D.A. Galloway, L.C. Gewin, H. Myers, W. Luo, C. Grandori, R.A. Katzenellenbogen, and J.K. McDougall Animal Models for CancerGenomic Progression in Mouse Models for Liver Tumors A.D. Tward, K.D. Jones, S. Yant, M.A. Kay, R. Wang, and J.M. BishopGenotype–Phenotype Relationships in a Mouse Model for Human Small–Cell Lung Cancer J. Calbo, R. Meuwissen, E. van Montfort, O. van Tellingen, and A. BernsCell Cycle and Cancer: Genetic Analysis of the Role of Cyclin–dependent Kinases M. Barbacid, S. Ortega, R. Sotillo, J. Odajima, A. Martin, D. Santamaria, P. Dubus, and M. MalumbresMouse Models of Human Non–Small–Cell Lung Cancer: Raising the Bar C.F.B. Kim, E.L. Jackson, D.G. Kirsch, J. Grimm, A.T. Shaw, K. Lane, J. Kissil, K.P. Olive, A. Sweet–Cordero, R. Weissleder, and T. JacksGeneration and Analysis of Genetically Defined Liver Carcinomas Derived from Bipotential Liver Progenitors L. Zender, W. Xue, C. Cordon–Cardo, G.J. Hannon, R. Lucito, S. Powers, P. Flemming, M.S. Spector, and S.W. LoweOncogene–dependent Tumor Suppression: Using the Dark Side of the Force for Cancer Therapy G.I. Evan, M. Christophorou, E.A. Lawlor, I. Ringshausen, J. Prescott, T. Dansen, A. Finch, C. Martins, and D. MurphyChromosomal Translocation Engineering to Recapitulate Primary Events of Human Cancer A. Forster, R. Pannell, L. Drynan, F. Cano, N. Chan, R. Codrington, A. Daser, N. Lobato, M. Metzler, C.–H. Nam, S. Rodriguez, T. Tanaka, and T. RabbittsDeciphering Cancer Complexities in Genetically Engineered Mice K. Simin, R. Hill, Y. Song, Q. Zhang, R. Bash, R.D. Cardiff, C. Yin, A. Xiao, K. McCarthy, and T. Van Dyke Gene Expression and CancerThe Evolving Portrait of Cancer Metastasis P.B. Gupta, S. Mani, J. Yang, K. Hartwell, and R.A. WeinbergGenomic Binding and Transcriptional Regulation by the DrosophilaMyc and Mnt Transcription Factors A. Orian, S.S. Grewal, P.S. Knoepfler, B.A. Edgar, S.M. Parkhurst, and R.N. EisenmanRegulation of the Arf/p53 Tumor Surveillance Network by E2F P.J. Iaquinta, A. Aslanian, and J.A. LeesGenetic and Epigenetic Changes in Mammary Epithelial Cells Identify a Subpopulation of Cells Involved in Early Carcinogenesis H. Berman, J. Zhang, Y.G. Crawford, M.L. Gauthier, C.A. Fordyce, K. McDermott, M. Sigaroudinia, K. Kozakiewicz, and T.D. TlstyEpigenetic Changes in Cancer and Preneoplasia J.G. HermanA Genetic Approach to Cancer Epigenetics A.P. Feinberg Tumor Responses to MicroenvironmentMicroenvironmental Regulators of Tissue Structure and Function Also Regulate Tumor Induction and Progression: The Role of Extracellular Matrix and Its Degrading Enzymes M.J. Bissell, P.A. Kenny, and D.C. RadiskyHow Do Cancer Cells Acquire the Fuel Needed to Support Cell Growth? C.B. Thompson, D.E. Bauer, J.J. Lum, G. Hatzivassiliou, W.–X. Zong, D. Ditsworth, F. Zhao, M. Buzzai, and T. LindstenMitochondria and Cancer: Warburg Addressed D.C. WallaceInductions of Complete Regressions of Oncogene–induced Breast Tumors in Mice R. Benezra, E. Henke, A. Ciarrocchi, M. Ruzinova, D. Solit, N. Rosen, D. Nolan, V. Mittal, and P. de CandiaThe Fibroblastic Coconspirator in Cancer Progression M. Egeblad, L.E. Littlepage, and Z. Werb AngiogenesisIs Oncogene Addiction Angiogenesis–dependent? J. Folkman and S. RyeomStructural Basis for the Functions of Endogenous Angiogenesis Inhibitors M.A. Grant and R. KalluriVEGF Trap as a Novel Antiangiogenic Treatment Currently in Clinical Trials for Cancer and Eye Diseases, and VelociGene–based Discovery of the Next Generation of Angiogenesis Targets J.S. Rudge, G. Thurston, S. Davis, N. Papadopoulos, N. Gale, S.J. Wiegand, and G.D. Yancopoulos Discovering Cancer TargetsMolecular Targeted Therapy of Lung Cancer: EGFR Mutations and Response to EGFR Inhibitors D.A. Haber, D.W. Bell, R. Sordella, E.L. Kwak, N. Godin–Heymann, S.V. Sharma, T.J. Lynch, and J. SettlemanAberrant Gene Silencing in Tumor Progression: Implications for Control of Cancer S.B. Baylin and W.Y. ChenDissecting Cancer Pathways and Vulnerabilities with RNAi T.F. Westbrook, F. Stegmeier, and S.J. ElledgeEmerging Approaches in Molecular Profiling Affecting Oncology Drug Discovery S.H. FriendScreens Using RNAi andStillman, Bruce is the author of 'Molecular Approaches to Controlling Cancer', published 2006 under ISBN 9780879697730 and ISBN 0879697733.