25962230
9781422304242
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Aspartame (AS) is an artificial sweetener used in food & beverages. Conventional 2-year rodent cancer studies of AS are considered negative, although a small number of neoplasms of the brain were observed in a rat study. The use of genetically altered mouse models as adjuncts to the 2-year rodent cancer assay has been explored. These models may prove to be more rapid, use fewer animals, & provide mechanistic insights into neoplastic responses. AS was tested for potential toxicity & carcinogenicity in 2 well-studied models. Under the conditions of this 9-month feed study, there was no evidence of carcinogenic activity of AS in male or female p53 haploin-sufficient mice exposed to 3,125, 6,250, 12,500, 25,000, or 50,000 ppm. Charts.Bucher, J. R. is the author of 'Genetically Modified Model Report on the Toxicology Studies of Aspartame and Carcinogenicity Studies of Aspartame', published 2006 under ISBN 9781422304242 and ISBN 1422304248.
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