Computer-Aided Drug Design Methods and Applications

Covering both methods and applications, this state-of-the-art volume focuses on computational and experimental techniques for computer-aided drug design (CADD). It discusses what pitfalls are encountered and how they can be overcome, and provides recent examples of successes and failures of various approaches. Completely referenced with 900 bibliographic citations of the literature -- including 1988 data -- and richly illustrated with drawings, tables, and black and white and color photographs, Computer-Aided Drug Design compares CADD to classical empirical medicinal chemical methodology ... discusses modern molecular modeling and molecular dynamics methods ... describes very new NMR techniques ... considers the use of x-ray crystal structures to design enzyme inhibitors ... offers never-before-published material on problems involved in the interpretation of enzyme inhibitor kinetics ... details the design of new angiotensin-converting enzyme inhibitors, renin inhibitors, antiviral agents, conformationally constrained neuroreceptor agonists, and antagonists ... plus more. An excellent reference for scientists involved in all phases of drug research and development, this book is also a valuable text for graduate students in pharmacology, medicinal chemistry, chemistry, and molecular biology. Book jacket.Propst, C. is the author of 'Computer-Aided Drug Design Methods and Applications' with ISBN 9780824780371 and ISBN 082478037X.